Evaluation of iron oxide nanoparticle biocompatibility.

TitleEvaluation of iron oxide nanoparticle biocompatibility.
Publication TypeJournal Article
Year of Publication2011
AuthorsHanini, A, Schmitt, A, Kacem, K, Chau, F, Ammar, S, Gavard, J
JournalInt J Nanomedicine
Volume6
Pagination787-94
Date Published2011
ISSN1178-2013
KeywordsAnalysis of Variance, Animals, Biocompatible Materials, Cell Line, Transformed, Cell Survival, Endothelial Cells, Ferric Compounds, Histocytochemistry, Humans, Intracellular Space, Magnetite Nanoparticles, Materials Testing, Particle Size, Rats, Tissue Distribution
Abstract

Nanotechnology is an exciting field of investigation for the development of new treatments for many human diseases. However, it is necessary to assess the biocompatibility of nanoparticles in vitro and in vivo before considering clinical applications. Our characterization of polyol-produced maghemite γ-Fe(2)O(3) nanoparticles showed high structural quality. The particles showed a homogeneous spherical size around 10 nm and could form aggregates depending on the dispersion conditions. Such nanoparticles were efficiently taken up in vitro by human endothelial cells, which represent the first biological barrier to nanoparticles in vivo. However, γ-Fe(2)O(3) can cause cell death within 24 hours of exposure, most likely through oxidative stress. Further in vivo exploration suggests that although γ-Fe(2)O(3) nanoparticles are rapidly cleared through the urine, they can lead to toxicity in the liver, kidneys and lungs, while the brain and heart remain unaffected. In conclusion, γ-Fe(2)O(3) could exhibit harmful properties and therefore surface coating, cellular targeting, and local exposure should be considered before developing clinical applications.

DOI10.2147/IJN.S17574
Alternate JournalInt J Nanomedicine
PubMed ID21589646
PubMed Central IDPMC3090275